Neuroactive Steroid Biosynthesis and Dynamic GABAA Receptor Reconfiguration in Postpartum Depression (NAS)

The purpose of this study is to better understand the biological causes of postpartum depression (PPD), a condition that affects up to 1 in 5 women after childbirth and may be more common in those with a history of mood disorders. This study is specifically evaluating the role of the neuroactive steroid (NAS) pathway and the gamma-aminobutyric acid (GABA) type A receptor in susceptibility to postpartum depression (PPD). The importance of this research to public health is that it may help scientists shift treatment from a reactive to a preventative approach, improve understanding of related conditions like Major Depressive Disorder (MDD), and support the development of targeted treatments and early identification strategies. Participants will complete a mental health assessment, psychological surveys, and have their blood drawn over about 10 months during pregnancy and postpartum.